Lipocalin-2 deficiency or blockade protects against aortic abdominal aneurysm development in mice.

doi:10.1093/cvr/cvw112

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Lipocalin-2 deficiency or blockade protects against aortic abdominal aneurysm development in mice.

Cardiovascular research - 1 Aug 2016

Tarín Carlos, Fernandez-Garcia Carlos Ernesto, Burillo Elena, Pastor-Vargas Carlos, Llamas-Granda Patricia, Castejón Borja, Ramos-Mozo Priscila, Torres-Fonseca Mónica M, Berger Thorsten, Mak Tak W, Egido Jesús, Blanco-Colio Luis M, Martín-Ventura Jose L

Abstract excerpt

AIMS: To study the role of lipocalin-2 (Lcn2) and the effect of Lcn2 blockade via anti-Lcn2 antibody in the development of abdominal aortic aneurysm (AAA). METHODS AND RESULTS: Expression mRNA and protein levels of Lcn2 and its human orthologue neutrophil gelatinase-associated lipocalin (NGAL) in aortic wall samples from experimental mouse and human AAA samples, respectively, were analysed by real-time PCR and...

Topics

Animals
Antibodies
Aorta, Abdominal
Aortic Aneurysm, Abdominal
Case-Control Studies
Cells, Cultured
Chemotaxis, Leukocyte
Dilatation, Pathologic
Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Elastin

Genetic Predisposition to Disease

Humans

Lipocalin-2

Matrix Metalloproteinases

Mice, Inbred C57BL

Mice, Knockout

Microvessels

Muscle, Smooth, Vascular

Source

Open in PubMed

Identifiers

PMID: 27229458
DOI: 10.1093/cvr/cvw112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lipocalin-2 deficiency or blockade protects against aortic abdominal aneurysm development in mice.PMID 27229458Read ↗

Macrophage-derived angiopoietin-like protein 2 accelerates development of abdominal aortic aneurysm.Semantic proximity Read ↗

Loss of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosisSemantic proximity Read ↗

PROTECTIVE ROLE FOR SMOOTH MUSCLE CELL HEPCIDIN IN ABDOMINAL AORTIC ANEURYSMSemantic proximity Read ↗

Inhibition of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosisSemantic proximity Read ↗

Lipocalin-2 contributes to experimental atherosclerosis in a stage-dependent manner.Semantic proximity Read ↗

Pathophysiology of abdominal aortic aneurysms: insights from the elastase-induced model in mice with different genetic backgrounds.Semantic proximity Read ↗

Cellular, Molecular and Clinical Aspects of Aortic Aneurysm-Vascular Physiology and Pathophysiology.Semantic proximity Read ↗

Divergent roles of matrix metalloproteinase 2 in pathogenesis of thoracic aortic aneurysm.Semantic proximity Read ↗

Ccn2 deletion predisposes to aortic aneurysm formation and death in mice which is partially reduced by mineralocorticoid receptor antagonist treatmentSemantic proximity Read ↗

Endothelium- and Fibroblast-Derived C-Type Natriuretic Peptide Prevents the Development and Progression of Aortic Aneurysm.Semantic proximity Read ↗

Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm.Semantic proximity Read ↗

Lymphangiogenesis in Abdominal Aortic Aneurysm regulates the balance between resident and circulating eosinophils via a 15-lipoxygenase-dependent mechanismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.