Article

Olfactory receptor 2 drives abdominal aortic aneurysm by promoting CX3CR1-mediated monocyte recruitment

2025-03-11

Abstract excerpt

<h4>Background</h4> Abdominal aortic aneurysms (AAA) are characterized by an intricate interplay of extracellular matrix degradation and inflammation. Macrophages are centrally involved in these processes. The mechanisms underlying macrophage activation in AAA remain incompletely understood. Vascular macrophages have been shown to express olfactory receptor 2 (Olfr2), a G-protein coupled receptor involved in medi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 67c54445-8f38-5e73-93de-e13054561c52
DOI: 10.1101/2025.02.28.640923

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Olfactory receptor 2 drives abdominal aortic aneurysm by promoting CX3CR1-mediated monocyte recruitmentDOI 10.1101/2025.02.28.640923Read

Olfr2-positive macrophages originate from monocytes proliferate in situ and present a pro-inflammatory foamy-like phenotype.Semantic proximity Read

Identification and Experimental Validation of NETosis-Mediated Abdominal Aortic Aneurysm Gene Signature Using Multi-omics, Machine Learning, and Mendelian RandomizationSemantic proximity Read

NCOR1 and NCOR2 Exhibit Distinct Cellular and Transcriptomic Signatures in Human Abdominal Aortic AneurysmSemantic proximity Read

Identification of key monocytes/macrophages related gene set of the early-stage abdominal aortic aneurysm by integrated bioinformatics analysis and experimental validationSemantic proximity Read

Spatial Transcriptomics Reveals <i>CXCL12</i> ⁺ Fibroblasts as Central Immune Organizers through CXCR4 Signaling in Abdominal Aortic AneurysmSemantic proximity Read

Comprehensive bioinformatics analysis revealed potential key genes and pathways underlying abdominal aortic aneurysmSemantic proximity Read

Screening key genes for abdominal aortic aneurysm based on gene expression omnibus dataset.Semantic proximity Read

Identification of Macrophage-Related Biomarkers for Abdominal Aortic Aneurysm through Combined Single-Cell Sequencing and Machine LearningSemantic proximity Read

Novel Pathways in the Pathobiology of Human Abdominal Aortic AneurysmsSemantic proximity Read

Inflammatory cell phenotypes in AAAs: their role and potential as targets for therapy.Semantic proximity Read

Identification of diagnostic biomarkers and therapeutic targets for abdominal aortic aneurysm via transcriptome sequencing and integrated bioinformaticsSemantic proximity Read

Adenosine 2A receptor modulates inflammation and phenotype in experimental abdominal aortic aneurysms.Semantic proximity Read