Article

Comparative therapeutic strategies for preventing aortic rupture in a mouse model of vascular Ehlers Danlos syndrome

2021-06-12

Abstract excerpt

We created a knock-in Col3a1 +/G182R mouse model with spontaneous mortality caused by thoracic aortic rupture that recapitulates a rare vascular genetic disease of type III collagen, the vascular Ehlers-Danlos syndrome (vEDS). Investigation of this model showed lower survival rate in males caused by aortic rupture, thin non-inflammatory arteries and altered arterial collagen. Transcriptomic analysis of aortas sho...

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Literature Corpus work: 8d062124-4937-55d6-bed6-742128d8cac8
DOI: 10.1101/2021.06.12.448202

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