Article

Osteopontin Upregulation Defines a Pre-Rupture State in Thoracic Aortic Aneurysms in Mice and Humans

2026-05-31

Abstract excerpt

<h4>Background</h4> Thoracic aortic aneurysm (TAA) is a life-threatening condition with an unpredictable lisk of rupture. Current clinical parameters have limited ability to accurately predict imminent rupture. Osteopontin (OPN) has been implicated in aortic aneurysm pathology, however, it role as a marker of imminent rupture remains. unclear. We investigated the dynamics of OPN expression dynamics in a mouse mod...

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Literature Corpus work: 5a893e5d-6b2f-5c60-8251-b7ff337bb237
DOI: 10.64898/2026.05.27.728313

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