Smooth muscle-specific deletion of cellular communication network factor 2 causes severe aorta malformation and atherosclerosis.

doi:10.1093/cvr/cvae174

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Article

Smooth muscle-specific deletion of cellular communication network factor 2 causes severe aorta malformation and atherosclerosis.

Cardiovascular research - 4 Dec 2024

Larsen Jannik H, Hegelund Julie S, Pedersen Matilde K, Andersson Cecilie M, Lindegaard Caroline A, Hansen Didde R, Stubbe Jane, Lindholt Jes S, Hansen Camilla S, Grentzmann Andrietta, Bloksgaard Maria, Jensen Boye L, Rodriguez-Díez Raúl R, Ruiz-Ortega Marta, Albinsson Sebastian, Pasterkamp Gerard, Mokry Michal, Leask Andrew, Goldschmeding Roel, Pilecki Bartosz, Sorensen Grith L, Pyke Charles, Overgaard Martin, Beck Hans C, Ketelhuth Daniel F J, Rasmussen Lars M, Steffensen Lasse B

Abstract excerpt

AIMS: Cellular communication network factor 2 (CCN2) is a matricellular protein implicated in fibrotic diseases, with ongoing clinical trials evaluating anti-CCN2-based therapies. By uncovering CCN2 as abundantly expressed in non-diseased artery tissue, this study aimed to investigate the hypothesis that CCN2 plays a pivotal role in maintaining smooth muscle cell (SMC) phenotype and protection against...

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Identifiers

PMID: 39167826
DOI: 10.1093/cvr/cvae174
PMCID: PMC11630017

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