Endothelium- and Fibroblast-Derived C-Type Natriuretic Peptide Prevents the Development and Progression of Aortic Aneurysm.

doi:10.1161/ATVBAHA.124.322350

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Endothelium- and Fibroblast-Derived C-Type Natriuretic Peptide Prevents the Development and Progression of Aortic Aneurysm.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2025

Aubdool Aisah A, Moyes Amie J, Perez-Ternero Cristina, Baliga Reshma S, Sanghera Jaspinder Singh, Syed M Taaha, Jaigirdar Kareemah, Panesar Anmolpreet K, Tsui Janice C, Li Yanming, Vasquez Hernan G, Shen Ying H, LeMaire Scott A, Raffort Juliette, Mallat Ziad, Lu Hong S, Daugherty Alan, Hobbs Adrian J

Abstract excerpt

BACKGROUND: Thoracic (TAA) and abdominal (AAA) aortic aneurysm are life-threatening diseases characterized by dilation, inflammation, and structural weakness; development of pharmacological therapies is desperately needed. CNP (C-type natriuretic peptide) plays a key role in vascular homeostasis, mediating vasodilator, anti-inflammatory, and antiatherogenic actions. Since such processes drive AA, we determined...

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PMID: 40177775
DOI: 10.1161/ATVBAHA.124.322350
PMCID: PMC12188825

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