Article
Basement membrane collagen IV deficiency promotes abdominal aortic aneurysm formation.
Scientific reports - 18 Jun 2021
Steffensen L B, Stubbe J, Lindholt J S, Beck H C, Overgaard M, Bloksgaard M, Genovese F, Holm Nielsen S, Tha M L T, Bang-Moeller S K, Hong Lin M K T, Larsen J H, Hansen D R, Jones G T, Bown M J, Karsdal M A, Rasmussen L M
Abstract excerpt
Abdominal aortic aneurysm (AAA) is a complex disease which is incompletely accounted for. Basement membrane (BM) Collagen IV (COL4A1/A2) is abundant in the artery wall, and several lines of evidence indicate a protective role of baseline COL4A1/A2 in AAA development. Using Col4a1/a2 hemizygous knockout mice (Col4a1/a2+/-, 129Svj background) we show that partial Col4a1/a2 deficiency augmented AAA formation....
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