Article

Isoform-specific translational control is evolutionarily conserved in primates

2023-04-22

Abstract excerpt

Alternative splicing (AS) alters messenger RNA (mRNA) coding capacity, localization, stability, and translation. Here we use comparative transcriptomics to identify cis-acting elements coupling AS to translational control (AS-TC). We sequenced total cytosolic and polyribosome-associated mRNA from human, chimpanzee, and orangutan induced pluripotent stem cells (iPSCs), revealing thousands of transcripts with splici...

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Literature Corpus work: 9a4dd88b-2d03-5f6b-9b3e-9832696e7135
DOI: 10.1101/2023.04.21.537863

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