Article

Ribosome profiling at isoform level reveals an evolutionary conserved impact of differential splicing on the proteome

2019-03-19

Abstract excerpt

The differential production of transcript isoforms from gene loci is a key cellular mechanism. Yet, its impact in protein production remains an open question. Here, we describe ORQAS (ORF quantification pipeline for alternative splicing), a new pipeline for the translation quantification of individual transcript isoforms using ribosome-protected mRNA fragments (Ribosome profiling). We found evidence of translation...

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Literature Corpus work: 257a2ddb-5947-5be3-b3ac-22ae058f46e3
DOI: 10.1101/582031

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