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Article

The splice of life: how alternative splicing shapes regulatory and phenotypic evolution.

The EMBO journal - 1 Mar 2026

Hunter Carissa Emerson, Xing Yi

Abstract excerpt

Alternative splicing (AS) is a key mechanism for generating regulatory and phenotypic diversity in multicellular eukaryotes. Large-scale comparative transcriptomic studies have revealed that AS leads to lineage-specific and tissue-specific transcriptomic and proteomic changes, underscoring its contribution to the evolution of gene products and functions. In this review, we highlight the patterns and mechanisms of...

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Identifiers

PMID: 41545761
DOI: 10.1038/s44318-025-00666-z
PMCID: PMC12992808

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