Article

Long read subcellular fractionation and sequencing reveals the translational fate of full length mRNA isoforms during neuronal differentiation

2024-02-23

Abstract excerpt

<h4>ABSTRACT</h4> Alternative splicing (AS) alters the cis-regulatory landscape of mRNA isoforms leading to transcripts with distinct localization, stability and translational efficiency. To rigorously investigate mRNA isoform-specific ribosome association, we generated subcellular fractionation and sequencing (Frac-seq) libraries using both conventional short reads and long reads from human embryonic stem cells...

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Literature Corpus work: 40a92418-d89d-5055-8546-fff172c6594a
DOI: 10.1101/2024.02.20.581280

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