Article
Integrative analysis of RNA, translation, and protein levels reveals distinct regulatory variation across humans.
Genome research - 1 Nov 2015
Cenik Can, Cenik Elif Sarinay, Byeon Gun W, Grubert Fabian, Candille Sophie I, Spacek Damek, Alsallakh Bilal, Tilgner Hagen, Araya Carlos L, Tang Hua, Ricci Emiliano, Snyder Michael P
Abstract excerpt
Elucidating the consequences of genetic differences between humans is essential for understanding phenotypic diversity and personalized medicine. Although variation in RNA levels, transcription factor binding, and chromatin have been explored, little is known about global variation in translation and its genetic determinants. We used ribosome profiling, RNA sequencing, and mass spectrometry to perform an...
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