Article

<i>SpliceImpactR</i> maps alternative RNA processing events driving protein functional diversity

2025-06-25

Abstract excerpt

<h4>Summary</h4> Alternative RNA processing is a key regulator of gene expression, driving transcript and proteomic diversity essential for cell function. However, the precise impacts of different alternative RNA processing events on protein function remain poorly understood. Here, we introduce SpliceImpactR, an open-source tool that systematically identifies RNA isoform switches—including alternative first and l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ec52bfc5-7912-5cc0-93de-17c85db24a2a
DOI: 10.1101/2025.06.20.660706

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>SpliceImpactR</i> maps alternative RNA processing events driving protein functional diversityDOI 10.1101/2025.06.20.660706Read

SpliceDecoder: A High-Throughput Tool for Guiding the Functional Interpretation of Differential Splicing EventsSemantic proximity Read

Biosurfer for systematic tracking of regulatory mechanisms leading to protein isoform diversitySemantic proximity Read

A genomic view of alternative splicing.Semantic proximity Read

Alternative mRNA processing sites decrease genetic variability while increasing functional diversity.Semantic proximity Read

Thousands of exon skipping events differentiate among splicing patterns in sixteen human tissuesSemantic proximity Read

Mechanisms and Regulation of Alternative Pre-mRNA Splicing.Semantic proximity Read

Splice junction centric approach to identify translated noncanonical isoforms in the human proteomeSemantic proximity Read

Human Messenger RNA Harbors Widespread Noncoding Splice IsoformsSemantic proximity Read

Widespread naturally variable human exons aid genetic interpretationSemantic proximity Read

Genetic variation of pre-mRNA alternative splicing in human populations.Semantic proximity Read

Exploring Disordered Regions of Human Spliceosome ProteinsSemantic proximity Read

Global impact of aberrant splicing on human gene expression levelsSemantic proximity Read