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Mechanostress-induced DNA damage in migrating neurons during brain development

2025-06-23

Abstract excerpt

<title>Abstract</title> <p>Migratory cells tend to have soft nuclei that deform and penetrate narrow spaces. Extensive nuclear deformation during migration can cause nuclear envelope rupture and DNA damage in cancer cells, which may contribute to the malignant transformation during tumor progression. However, the significance of DNA damage in physiological migration is less well understood. Here, we demonstrate t...

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Identifiers and source

Literature Corpus work
9a45ca6a-2ce1-5041-bb7c-2f9649471bec
DOI
10.21203/rs.3.rs-6836425/v1
Open publication

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Mechanostress-induced DNA damage in migrating neurons during brain developmentDOI 10.21203/rs.3.rs-6836425/v1
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