Article

Neuronal migration induces DNA damage in developing brain

2025-06-10

Abstract excerpt

Migratory cells tend to have soft nuclei that deform and penetrate narrow spaces 1,2 . Extensive nuclear deformation during migration can cause nuclear envelope rupture and DNA damage in cancer cells, which may contribute to the malignant transformation during tumor progression 3,4,5,6 . However, the significance of DNA damage in physiological migration is less well understood. Here, we demonstrate that the migr...

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Literature Corpus work: 67b02317-d3f0-591d-bfe4-3adc120fab29
DOI: 10.1101/2025.06.10.658810

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