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DNA Repair Deficiency and Neurodegeneration

1 Oct 2007

Abstract excerpt

Defects in the response to DNA single-strand or double-strand breaks underpin many human diseases associated with disorders of the nervous system. During nervous system development endogenous DNA damage often results in apoptosis, although cell replacement can occur from germinal zones within this rapidly proliferating tissue. However, if this damage surveillance is faulty, cells with genomic damage may...

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PMID: 17700067
DOI: 10.4161/cc.6.19.4757

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