Article

AMP accumulation during mitochondrial stress induces transcription of cytosolic and mitochondrial protein synthesis components via NHR-180

2025-01-23

Abstract excerpt

The mitochondrial unfolded protein response (UPR mt ), which promotes mitochondrial proteostasis and biogenesis is regulated by the transcription factor ATFS-1. In C. elegans , impaired atfs-1 expression perturbs mitochondrial function and slows development. Here, via an RNAi suppressor screen, we found that inhibition of the nuclear hormone receptor NHR-180 increases mitochondrial function and the rate of deve...

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Identifiers and source

Literature Corpus work: 9a1f35d3-12d5-5347-a604-f6fe069e9336
DOI: 10.1101/2025.01.22.634344

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