Article

Cognate amino acid therapies provide preclinical benefit in 19 <i>C. elegans</i> models of ARS2 deficiency

2026-02-05

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial aminoacyl-tRNA synthetases (mt-ARS) are essential mitochondrial translation machinery components that catalyze mitochondrial transfer RNAs (tRNAs) charging with their cognate amino acid. Although mt-ARS have a common biochemical function, patients with mt-ARS pathogenic variants commonly develop neurological disorders with varying phenotypes, severity spectrum, and age of onset. Co...

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Literature Corpus work: 74963fc2-ff59-51a3-9b0f-e8fe5da53540
DOI: 10.64898/2026.02.03.703549

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