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Article

Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response

15 Nov 2022

Abstract excerpt

Impairment of translation can lead to collisions of ribosomes, which constitute an activation platform for several ribosomal stress-surveillance pathways. Among these is the ribotoxic stress response (RSR), where ribosomal sensing by the MAP3K ZAKα leads to activation of p38 and JNK kinases. Despite these insights, the physiological ramifications of ribosomal impairment and downstream RSR signaling remain...

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PMID: 36384144
DOI: 10.1016/j.cmet.2022.10.011

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