Article

Mitochondrial genome recovery by ATFS-1 is essential for development following starvation

2022-05-19

Abstract excerpt

<h4>ABSTRACT</h4> Nutrient availability regulates the C. elegans life cycle as well as mitochondrial physiology. Food deprivation significantly reduces mitochondrial genome (mtDNA) number and leads to aging-related phenotypes. Here, we demonstrate that the bZIP protein ATFS-1, a mediator of the mitochondrial unfolded protein response (UPR mt ), is required to promote growth and establish a functional germline f...

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Literature Corpus work: 2af10196-69ff-5ba1-9178-7b0b195091df
DOI: 10.1101/2022.05.19.492689

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