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Article

A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways.

Cell metabolism - 3 Mar 2020

Molenaars Marte, Janssens Georges E, Williams Evan G, Jongejan Aldo, Lan Jiayi, Rabot Sylvie, Joly Fatima, Moerland Perry D, Schomakers Bauke V, Lezzerini Marco, Liu Yasmine J, McCormick Mark A, Kennedy Brian K, van Weeghel Michel, van Kampen Antoine H C, Aebersold Ruedi, MacInnes Alyson W, Houtkooper Riekelt H

Abstract excerpt

Slowing down translation in either the cytosol or the mitochondria is a conserved longevity mechanism. Here, we found a non-interventional natural correlation of mitochondrial and cytosolic ribosomal proteins (RPs) in mouse population genetics, suggesting a translational balance. Inhibiting mitochondrial translation in C. elegans through mrps-5 RNAi repressed cytosolic translation. Transcriptomics integrated with...

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Identifiers

PMID: 32084377
DOI: 10.1016/j.cmet.2020.01.011
PMCID: PMC7214782

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