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Article

Identification of an uncharacterized gene as a mitochondrial methionine tRNA synthetase in Caenorhabditis elegans.

G3 (Bethesda, Md.) - 4 Feb 2026

Thapa Bharat Vivan, Das Mohit, Taylor David I, Held James P, Patel Maulik R

Abstract excerpt

Aminoacyl-tRNA synthetases (aaRSs) are essential for translation, as they charge tRNA molecules with their corresponding amino acids. Alterations in aaRSs can significantly disrupt both cytosolic and mitochondrial translation. Through a forward genetic screen for mitochondrial unfolded protein response (UPRmt) activators in Caenorhabditis elegans, we identified a missense mutation (P447V) in the previously...

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Identifiers

PMID: 41359510
DOI: 10.1093/g3journal/jkaf298
PMCID: PMC12869082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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