Article

Sex differences in colonic inflammation are driven by epithelial-specific expression of estrogen receptor alpha

2024-09-30

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background & Aims</h4> Inflammatory bowel disease (IBD) patients exhibit altered expression of nuclear estrogen receptors alpha and beta (ERα, ERβ) and G-protein coupled estrogen receptor 1 (GPER1). We previously showed that deletion of ERα protects against intestinal damage selectively in female mice; however, the mechanisms conferring sex-specific protection are poorly understood. The goa...

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Literature Corpus work: 99f4f203-a585-54b6-873b-c78a0fa040f6
DOI: 10.1101/2024.09.28.615598

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