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Article

The ESRP1-GPR137 axis contributes to intestinal pathogenesis

4 Oct 2017

Abstract excerpt

Aberrant alternative pre-mRNA splicing (AS) events have been associated with several disorders. However, it is unclear whether deregulated AS directly contributes to disease. Here, we reveal a critical role of the AS regulator epithelial splicing regulator protein 1 (ESRP1) for intestinal homeostasis and pathogenesis. In mice, reduced ESRP1 function leads to impaired intestinal barrier integrity, increased...

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PMID: 28975893
DOI: 10.7554/elife.28366

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