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Article

Disruption of estrogen receptor signaling enhances intestinal neoplasia in Apc Min/+ mice

11 Jun 2009

Abstract excerpt

Estrogen receptors (ERs) [ERalpha (Esr1) and ERbeta (Esr2)] are expressed in the human colon, but during the multistep process of colorectal carcinogenesis, expression of both ERalpha and ERbeta is lost, suggesting that loss of ER function might promote colorectal carcinogenesis. Through crosses between an ERalpha knockout and Apc(Min) mouse strains, we demonstrate that ERalpha deficiency is associated with a...

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PMID: 19520794
DOI: 10.1093/carcin/bgp132

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