Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estrogen Receptors in Colorectal Cancer: Facts, Novelties and Perspectives

20 Oct 2021

Abstract excerpt

Colorectal cancer (CRC) is the second cause of cancer-related death in both sexes worldwide. As pre-menopausal women are less likely to develop CRC compared to age-matched men, a protective role for estrogens has been hypothesized. Indeed, two isoforms of nuclear estrogen receptors (ER) have been described: ERα and ERβ. While the binding of 17beta-estradiol to ERα activates anti-apoptotic pathways, the...

Topics

Join the communities discussing this publication.

Cytokine Signaling Pathways and Interactions
Estrogen and related hormone effects
Helicobacter pylori-related gastroenterology studies

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34898546
DOI: 10.3390/curroncol28060361

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estrogen Receptors in Colorectal Cancer: Facts, Novelties and PerspectivesPMID 34898546Read ↗

Sex Steroid Receptors in Colorectal Cancer: Implications for Tumor Progression, Therapeutic Opportunities, and Sex-Specific OutcomesSemantic proximity Read ↗

Oestrogen receptor-related receptor alpha (ERRα) and oestrogen receptors (ERα and ERβ) exhibit different gene expression in human colorectal tumour progressionSemantic proximity Read ↗

Colorectal Cancer: Causes and Evidence of Chemopreventive TreatmentsSemantic proximity Read ↗

Roles of estrogen receptor α in endometrial carcinoma (Review)Semantic proximity Read ↗

Estrogen and colon cancer:current issuesSemantic proximity Read ↗

Delineating the role of nuclear receptors in colorectal cancer, a focused reviewSemantic proximity Read ↗

Estrogen receptors in gastric cancer: Advances and perspectivesSemantic proximity Read ↗

Epigenetic down regulation of G protein-coupled estrogen receptor (GPER) functions as a tumor suppressor in colorectal cancerSemantic proximity Read ↗

Association of estrogen receptor beta variants and serum levels of estradiol with risk of colorectal cancer: a case control study.Semantic proximity Read ↗

Mechanisms for estrogen receptor expression in human cancerSemantic proximity Read ↗

Genome‐wide estrogen receptor β chromatin binding in human colon cancer cells reveals its tumor suppressor activitySemantic proximity Read ↗

Genome-wide DNA methylation differences according to oestrogen receptor beta status in colorectal cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.