Article

The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis

2018-09-24

Abstract excerpt

The gene encoding for Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) is a risk gene for inflammatory bowel disease (IBD). Together with its oxysterol ligand 7α,25-dihydroxycholesterol, EBI2 mediates migration and differentiation of immune cells. However, the role of EBI2 in the colonic immune system remains insufficiently studied. We found increased mRNA expression of EBI2 and oxysterol synthesizin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0ee2df74-cfa6-5959-a3aa-aad71f538db2
DOI: 10.1101/424937

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitisDOI 10.1101/424937Read

A high cholesterol diet aggravates experimental colitis through SREBP2-modulated endocytosis and degradation of occludin and Zo-1 proteins.Semantic proximity Read

EBI2 in splenic and local immune responses and in autoimmunitySemantic proximity Read

Eosinophil-derived COX-2 protects against experimental colitis through the PGE <sub>2</sub> -IL-22 axisSemantic proximity Read

Interleukin-35 mediates mucosal immune responses that protect against T-cell-dependent colitis.Semantic proximity Read

Sex differences in colonic inflammation are driven by epithelial-specific expression of estrogen receptor alphaSemantic proximity Read

A single nucleotide polymorphism in the gene for GPR183 increases its surface expression on blood lymphocytes of patients with inflammatory bowel disease.Semantic proximity Read

IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitisSemantic proximity Read

Anti-microbial Functions of Group 3 Innate Lymphoid Cells in Gut-Associated Lymphoid Tissues Are Regulated by G-Protein-Coupled Receptor 183Semantic proximity Read

Epigenetic histone modulation contributes to improvements in inflammatory bowel disease via EBI3.Semantic proximity Read

Transcription factor EB modulates the homeostasis of reactive oxygen species in intestinal epithelial cells to alleviate inflammatory bowel diseaseSemantic proximity Read

Butyrate ameliorates inflammation in colon biopsy samples of IBD patients and experimental colitis in mice involving RNA binding protein, AUF1-IL-27 axis and accelerating B1a to B10 polarizationSemantic proximity Read

Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivoSemantic proximity Read