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Article

Epigenetic down regulation of G protein-coupled estrogen receptor (GPER) functions as a tumor suppressor in colorectal cancer

5 May 2017

Abstract excerpt

BACKGROUND: Estrogenic signals are suggested to have protection roles in the development of colorectal cancer (CRC). The G protein-coupled estrogen receptor (GPER) has been reported to mediate non-genomic effects of estrogen in hormone related cancers except CRC. Its expression and functions in CRC were investigated. METHODS: The expression of GPER and its associations with clinicopathological features were...

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PMID: 28476123
DOI: 10.1186/s12943-017-0654-3

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