Article

High-fat diet impacts the colon and its transcriptome in a sex-dependent manner that is modifiable by estrogens

2020-06-04

Abstract excerpt

Epidemiological studies highlight a strong association between obesity and colorectal cancer (CRC), especially in men. Estrogen, on the other hand, is associated with protection against both the metabolic syndrome and CRC. The colon is the first organ to respond to a high-fat diet (HFD), and estrogen receptor beta (ERβ) in the intestine appears to prevent CRC. How estrogen impacts the colon under HFD condition has...

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Literature Corpus work: 8baf90fa-48f6-554f-9551-ef6c3690651b
DOI: 10.1101/2020.06.03.131771

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