Article

Diet-induced obesity mediated through Estrogen-Related Receptor α is independent of intestinal function

2024-07-16

Abstract excerpt

<h4>Summary</h4> Obesity has become an epidemic, prompting advances in therapies targeting this condition. Estrogen-related receptor α (ESRRA), a transcription factor, plays pivotal roles in energy metabolism across diverse tissues. Studies have demonstrated that loss of Esrra leads to fat malabsorption and resistance to diet-induced obesity. However, the reliance of these studies on germline Esrra mutants over...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c924aefe-cfe1-5a3d-a256-afff56b0fcb4
DOI: 10.1101/2024.07.10.602978

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Diet-induced obesity mediated through Estrogen-Related Receptor α is independent of intestinal functionDOI 10.1101/2024.07.10.602978Read

High-fat diet impacts the colon and its transcriptome in a sex-dependent manner that is modifiable by estrogensSemantic proximity Read

Estrogen-related Receptor α (ERRα) Is a Transcriptional Regulator of Apolipoprotein A-IV and Controls Lipid Handling in the IntestineSemantic proximity Read

Loss of ERα partially reverses the effects of maternal high-fat diet on energy homeostasis in female mice.Semantic proximity Read

Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha.Semantic proximity Read

Sex differences in colonic inflammation are driven by epithelial-specific expression of estrogen receptor alphaSemantic proximity Read

Hepatocyte ERα orchestrates sex-specific liver adaptation to fasting and feeding statesSemantic proximity Read

Metabolic and Epigenetic Regulation by Estrogen in AdipocytesSemantic proximity Read

Role of RSPO3 in Estrogen-mediated Sex Differences in Body Fat Distribution: A Single-cell Data-driven StudySemantic proximity Read

Epigenetic programming of estrogen receptor in adipocytes by high-fat diet regulates obesity-induced inflammationSemantic proximity Read

Epigenetic Programming of Estrogen Receptor in Adipose Tissue by High Fat Diet Regulates Obesity-Induced InflammationSemantic proximity Read

Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor αSemantic proximity Read

Estrogen receptor activation remodels TEAD1 gene expression to alleviate hepatic steatosisSemantic proximity Read