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Article

An overview of mutational and copy number signatures in human cancer.

The Journal of pathology - 1 Jul 2022

Steele Christopher D, Pillay Nischalan, Alexandrov Ludmil B

Abstract excerpt

The genome of each cell in the human body is constantly under assault from a plethora of exogenous and endogenous processes that can damage DNA. If not successfully repaired, DNA damage generally becomes permanently imprinted in cells, and all their progenies, as somatic mutations. In most cases, the patterns of these somatic mutations contain the tell-tale signs of the mutagenic processes that have imprinted and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35420163
DOI: 10.1002/path.5912
PMCID: PMC9324981

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