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Article

Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies.

The Journal of biological chemistry - 22 Dec 2017

Casey Amanda K, Moehlman Andrew T, Zhang Junmei, Servage Kelly A, Krämer Helmut, Orth Kim

Abstract excerpt

Protein chaperones play a critical role in proteostasis. The activity of the major endoplasmic reticulum chaperone BiP (GRP78) is regulated by Fic-mediated AMPylation during resting states. By contrast, during times of stress, BiP is deAMPylated. Here, we show that excessive AMPylation by a constitutively active FicE247G mutant is lethal in Drosophila This lethality is cell-autonomous, as directed expression of...

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Identifiers

PMID: 29089387
DOI: 10.1074/jbc.M117.799296
PMCID: PMC5743091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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