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The Unfolded Protein Response in Secretory Cell Function

30 Aug 2012

Abstract excerpt

The endoplasmic reticulum (ER) controls many important aspects of cellular function, including processing of secreted and membrane proteins, synthesis of membranes, and calcium storage. Maintenance of ER function is controlled through a network of signaling pathways collectively known as the unfolded protein response (UPR). The UPR balances the load of incoming proteins with the folding capacity of the ER and...

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PMID: 22934644
DOI: 10.1146/annurev-genet-110711-155644

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