Article
A Unique ISR Program Determines Cellular Responses to Chronic Stress.
Molecular cell - 7 Dec 2017
Guan Bo-Jhih, van Hoef Vincent, Jobava Raul, Elroy-Stein Orna, Valasek Leos S, Cargnello Marie, Gao Xing-Huang, Krokowski Dawid, Merrick William C, Kimball Scot R, Komar Anton A, Koromilas Antonis E, Wynshaw-Boris Anthony, Topisirovic Ivan, Larsson Ola, Hatzoglou Maria
Abstract excerpt
The integrated stress response (ISR) is a homeostatic mechanism induced by endoplasmic reticulum (ER) stress. In acute/transient ER stress, decreased global protein synthesis and increased uORF mRNA translation are followed by normalization of protein synthesis. Here, we report a dramatically different response during chronic ER stress. This chronic ISR program is characterized by persistently elevated uORF mRNA...
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