Article

Dysregulation of FicD AMPylation causes diabetes by disrupting pancreatic endocrine homeostasis

2024-10-26

Abstract excerpt

Bi-functional enzyme FicD regulates the endoplasmic reticulum chaperone BiP using AMPylation and deAMPylation during ER homeostasis and stress, respectively. Human FicD with an arginine-to-serine mutation disrupts FicD deAMPylation activity resulting in severe neonatal diabetes. We generated the FicD R371S mutation in mice to create a pre-clinical murine model for neonatal diabetes. We observed elevated BiP AMPyl...

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Literature Corpus work: 0f64ef14-4df3-55a7-859f-6cd8c4dd3619
DOI: 10.1101/2024.10.25.620287

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