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Article

ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress.

Developmental cell - 1 Sept 2007

Wu Jun, Rutkowski D Thomas, Dubois Meghan, Swathirajan Jayanth, Saunders Thomas, Wang Junying, Song Benbo, Yau Grace D-Y, Kaufman Randal J

Abstract excerpt

In vertebrates, three proteins--PERK, IRE1alpha, and ATF6alpha--sense protein-misfolding stress in the ER and initiate ER-to-nucleus signaling cascades to improve cellular function. The mechanism by which this unfolded protein response (UPR) protects ER function during stress is not clear. To add...

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Identifiers

PMID: 17765679
DOI: 10.1016/j.devcel.2007.07.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17765679-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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