QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis

Abstract excerpt

Tissue homeostasis is perturbed in a diversity of inflammatory pathologies. These changes can elicit endoplasmic reticulum (ER) stress, protein misfolding, and cell death. ER stress triggers the unfolded protein response (UPR), which can promote recovery of ER proteostasis and cell survival or trigger programmed cell death. Here, we leveraged single-cell RNA sequencing to define dynamic transcriptional states...

Topics

Join the communities discussing this publication.

• Autophagy in Disease and Therapy
• Endoplasmic Reticulum Stress and Disease
• RNA regulation and disease