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Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

2019-09-27

Abstract excerpt

<h4>ABSTRACT</h4> Age is the dominant risk factor for most chronic human diseases; yet the mechanisms by which aging confers this risk are largely unknown. 1 Recently, the age-related acquisition of somatic mutations in regenerating hematopoietic stem cell populations was associated with both hematologic cancer incidence 2–4 and coronary heart disease prevalence. 5 Somatic mutations with leukemogenic potential...

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Literature Corpus work
99e28b19-909e-5841-be72-7380d038aa67
DOI
10.1101/782748
Open publication

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Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole GenomesDOI 10.1101/782748
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