Article

A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic datasets

2022-10-25

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) is a common form of age-related somatic mosaicism that is associated with significant morbidity and mortality. CHIP mutations can be identified in peripheral blood samples sequenced using approaches that cover the whole genome, whole exome or targeted genetic regions; however, differentiating true CHIP mutations from sequencing artifacts and germline variants...

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Literature Corpus work: e06150cc-cb05-5e54-8a04-5cf1debd9722
DOI: 10.1101/2022.10.21.22281368

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