Article

Genome-wide characterization of clonal hematopoiesis reveals extensive non-coding putative driver mutations

2025-10-14

Abstract excerpt

As humans age, we acquire somatic mutations in our blood, leading to clonal hematopoiesis (CH). Despite the prevalence of CH in aged individuals, recent searches for selective sweeps in single-cell derived colonies have revealed that most clones have expanded without a known driver mutation. This extensive, unexplained CH motivated our search for novel driver mutations across ∼490K blood whole genome sequences fro...

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Literature Corpus work: 4e8bd08f-959e-5ab1-8f55-725394ceb110
DOI: 10.1101/2025.10.12.25337792

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