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Article

A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets.

Blood - 4 May 2023

Vlasschaert Caitlyn, Mack Taralynn, Heimlich J Brett, Niroula Abhishek, Uddin Md Mesbah, Weinstock Joshua, Sharber Brian, Silver Alexander J, Xu Yaomin, Savona Michael, Gibson Christopher, Lanktree Matthew B, Rauh Michael J, Ebert Benjamin L, Natarajan Pradeep, Jaiswal Siddhartha, Bick Alexander G

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) is a common form of age-related somatic mosaicism that is associated with significant morbidity and mortality. CHIP mutations can be identified in peripheral blood samples that are sequenced using approaches that cover the whole genome, the whole exome, or targeted genetic regions; however, differentiating true CHIP mutations from sequencing artifacts and...

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Identifiers

PMID: 36652671
DOI: 10.1182/blood.2022018825
PMCID: PMC10273159

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