Article
Clonal Hematopoiesis of Indeterminate Potential (CHIP) and Incident Type 2 Diabetes Risk.
Diabetes care - 1 Nov 2023
Tobias Deirdre K, Manning Alisa K, Wessel Jennifer, Raghavan Sridharan, Westerman Kenneth E, Bick Alexander G, Dicorpo Daniel, Whitsel Eric A, Collins Jason, Correa Adolfo, Cupples L Adrienne, Dupuis Josée, Goodarzi Mark O, Guo Xiuqing, Howard Barbara, Lange Leslie A, Liu Simin, Raffield Laura M, Reiner Alex P, Rich Stephen S, Taylor Kent D, Tinker Lesley, Wilson James G, Wu Peitao, Carson April P, Vasan Ramachandran S, Fornage Myriam, Psaty Bruce M, Kooperberg Charles, Rotter Jerome I, Meigs James, Manson JoAnn E
Abstract excerpt
OBJECTIVE: Clonal hematopoiesis of indeterminate potential (CHIP) is an aging-related accumulation of somatic mutations in hematopoietic stem cells, leading to clonal expansion. CHIP presence has been implicated in atherosclerotic coronary heart disease (CHD) and all-cause mortality, but its association with incident type 2 diabetes (T2D) is unknown. We hypothesized that CHIP is associated with elevated risk of...
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