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A novel framework for characterizing genomic haplotype diversity in the human immunoglobulin heavy chain locus

2020-04-20

Abstract excerpt

An incomplete ascertainment of genetic variation within the highly polymorphic immunoglobulin heavy chain locus (IGH) has hindered our ability to define genetic factors that influence antibody and B cell mediated processes. To date, methods for locus-wide genotyping of all IGH variant types do not exist. Here, we combine targeted long-read sequencing with a novel bioinformatics tool, IGenotyper, to fully character...

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Literature Corpus work
998b89e5-d7a5-557d-ac47-85c52b02457e
DOI
10.1101/2020.04.19.049270
Open publication

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A novel framework for characterizing genomic haplotype diversity in the human immunoglobulin heavy chain locusDOI 10.1101/2020.04.19.049270
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