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Resolving haplotype variation and complex genetic architecture in the human immunoglobulin kappa chain locus in individuals of diverse ancestry

2023-10-25

Abstract excerpt

Immunoglobulins (IGs), critical components of the human immune system, are composed of heavy and light protein chains encoded at three genomic loci. The IG Kappa (IGK) chain locus consists of two large, inverted segmental duplications. The complexity of IG loci has hindered effective use of standard high- throughput methods for characterizing genetic variation within these regions. To overcome these limitations, w...

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Literature Corpus work
926eaa96-eec1-5b36-90f4-a144d34d7c26
DOI
10.1101/2023.10.23.563321
Open publication

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Resolving haplotype variation and complex genetic architecture in the human immunoglobulin kappa chain locus in individuals of diverse ancestryDOI 10.1101/2023.10.23.563321
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