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Novel Genes and Polymorphisms in Human Immunoglobulin Light Chains Across Diverse Populations Through Comprehensive IMGT Analysis

2025-09-27

Abstract excerpt

The human immunoglobulin light chain loci, kappa (IGK) and lambda (IGL), are structurally complex genomic regions with germline gene content that is not yet fully characterized. These loci are marked by extensive gene duplication, allelic diversity, and segmental duplications, features that contribute critically to the adaptive immune response. In this study, we present a comprehensive IMGT annotation of IGK and I...

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Literature Corpus work
31fe1e27-0954-5e8b-b870-12d753d1c3fc
DOI
10.1101/2025.09.25.678462
Open publication

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