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Article

A Novel Framework for Characterizing Genomic Haplotype Diversity in the Human Immunoglobulin Heavy Chain Locus.

Frontiers in immunology - 1 Jan 2020

Rodriguez Oscar L, Gibson William S, Parks Tom, Emery Matthew, Powell James, Strahl Maya, Deikus Gintaras, Auckland Kathryn, Eichler Evan E, Marasco Wayne A, Sebra Robert, Sharp Andrew J, Smith Melissa L, Bashir Ali, Watson Corey T

Abstract excerpt

An incomplete ascertainment of genetic variation within the highly polymorphic immunoglobulin heavy chain locus (IGH) has hindered our ability to define genetic factors that influence antibody-mediated processes. Due to locus complexity, standard high-throughput approaches have failed to accurately and comprehensively capture IGH polymorphism. As a result, the locus has only been fully characterized two times,...

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Identifiers

PMID: 33072076
DOI: 10.3389/fimmu.2020.02136
PMCID: PMC7539625

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