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Resolving haplotype variation and complex genetic architecture in the human immunoglobulin kappa chain locus in individuals of diverse ancestry.

Genes and immunity - 1 Aug 2024

Engelbrecht Eric, Rodriguez Oscar L, Shields Kaitlyn, Schultze Steven, Tieri David, Jana Uddalok, Yaari Gur, Lees William D, Smith Melissa L, Watson Corey T

Abstract excerpt

Immunoglobulins (IGs), critical components of the human immune system, are composed of heavy and light protein chains encoded at three genomic loci. The IG Kappa (IGK) chain locus consists of two large, inverted segmental duplications. The complexity of the IG loci has hindered use of standard high-throughput methods for characterizing genetic variation within these regions. To overcome these limitations, we use...

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Identifiers

PMID: 38844673
DOI: 10.1038/s41435-024-00279-2
PMCID: PMC11327106

Genes

IGK

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