Article

Accurate Simulation of Coupling between Protein Secondary Structure and Liquid-Liquid Phase Separation

2023-08-23

Abstract excerpt

Intrinsically disordered proteins (IDPs) frequently mediate liquid-liquid phase separation (LLPS) that underlies the formation of membraneless organelles. Together with theory and experiment, efficient coarse-grained (CG) simulations have been instrumental in understanding sequence- specific phase separation of IDPs. However, the widely-used Cα-only models are severely limited in capturing the peptide nature of ID...

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Literature Corpus work: 997fcaed-0512-5549-88a3-ea47af522236
DOI: 10.1101/2023.08.22.554378

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