Article

TDP-43 α-helical structure tunes liquid-liquid phase separation and function

2019-05-18

Abstract excerpt

Liquid-liquid phase separation (LLPS) is involved in the formation of membraneless organelles (MLOs) associated with RNA processing. Present in several MLOs, TDP-43 undergoes LLPS and is linked to the pathogenesis of amyotrophic lateral sclerosis (ALS). While some disease variants of TDP-43 disrupt self-interaction and function, here we show that designed single mutations can enhance TDP-43 assembly and function v...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 93286975-5b7a-56fa-9d63-758de0293364
DOI: 10.1101/640615

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TDP-43 α-helical structure tunes liquid-liquid phase separation and functionDOI 10.1101/640615Read

TDP-43 α-helical structure tunes liquid-liquid phase separation and function.Semantic proximity Read

ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain.Semantic proximity Read

Cellular modifiers of TDP-43 phase transition and cytoplasmic aggregationSemantic proximity Read

Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregationSemantic proximity Read

Aliphatic residues contribute significantly to the phase separation of TDP-43 C-terminal domainSemantic proximity Read

TAR DNA-binding protein 43 (TDP-43) liquid-liquid phase separation is mediated by just a few aromatic residues.Semantic proximity Read

Phase to Phase with TDP-43.Semantic proximity Read

Phase separation behavior of TDP-43 governs its protein interactome and regulation of alternative splicingSemantic proximity Read

Influence of ALS-linked M337V mutation on the conformational ensembles of TDP-43321-340 peptide monomer and dimer.Semantic proximity Read

Uncovering Intermolecular Interactions Driving the Liquid-Liquid Phase Separation of the TDP-43 Low-Complexity Domain via Atomistic Dimerization Simulations.Semantic proximity Read

Pathological C-terminal phosphomimetic substitutions alter the mechanism of liquid-liquid phase separation of TDP-43 low complexity domainSemantic proximity Read

Phase Behavior of TDP-43 and hnRNPH1: From Soluble and Aggregated States to Liquid-Like DropletsSemantic proximity Read