Sequence determinants of protein phase behavior from a coarse-grained model.

Abstract excerpt

Membraneless organelles important to intracellular compartmentalization have recently been shown to comprise assemblies of proteins which undergo liquid-liquid phase separation (LLPS). However, many proteins involved in this phase separation are at least partially disordered. The molecular mechanism and the sequence determinants of this process are challenging to determine experimentally owing to the disordered...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Hydrophobic and Hydrophilic Interactions
• Share to Organelles